Journal article
Bone Microarchitecture in Transgender Adults: A Cross-Sectional Study
I Bretherton, A Ghasem-Zadeh, SY Leemaqz, E Seeman, X Wang, T McFarlane, C Spanos, M Grossmann, JD Zajac, AS Cheung
Journal of Bone and Mineral Research | Published : 2022
DOI: 10.1002/jbmr.4497
Abstract
Gender-affirming hormone therapy aligns physical characteristics with an individual's gender identity, but sex hormones regulate bone remodeling and influence bone morphology. We hypothesized that trans men receiving testosterone have compromised bone morphology because of suppression of ovarian estradiol production, whereas trans women receiving estradiol, with or without anti-androgen therapy, have preserved bone microarchitecture. We compared distal radial and tibial microarchitecture using high-resolution peripheral quantitative computed tomography images in a cross-sectional study of 41 trans men with 71 cis female controls, and 40 trans women with 51 cis male controls. Between-group di..
View full abstractGrants
Awarded by Sylvia and Charles Viertel Charitable Foundation
Funding Acknowledgements
IB is supported by an Australian Government Research Training Program Scholarship and a Rowden White Scholarship (application ref: 184409), The University of Melbourne. ASC is supported by an Australian Government National Health and Medical Research Council Early Career Fellowship (#1143333) and receives research support by the Viertel Charitable Foundation Clinical Investigator Award, Endocrine Society of Australia, Austin Medical Research Foundation, and the Royal Australasian College of Physicians Foundation. Study data were collected and managed using REDCap electronic data capture tools hosted at University of Melbourne. No sponsor or funding source was involved in the study design, collection, analysis, and interpretation of data, in the decision to submit the manuscript for publication, or any other aspect of the study.